Look at these sentences using depuis que:
Depuis que je t'ai rencontré, ma vie a complètement changé.Since I met you, my life has changed completely!
Depuis que j'ai quatre ans, je porte des lunettes.Ever since I was four, I've been wearing glasses.
Nous le savons depuis que vous nous l'avez dit.We've known [it] since you told us.
Note that to express since in the sense of "since a point in time" followed by a conjugated verb, in French you use depuis que + verb in L'Indicatif.
ATTENTION: You can never omit the que.
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